Spontaneous tumour lysis syndrome

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Spontaneous Tumour Lysis Syndrome in a Multiple Myeloma

The tumor lysis syndrome (TLS) is a collection of metabolic abnormalities that occur in consequence of the release of intracellular contents following lysis of tumor cells. TLS occurs spontaneously or after chemotherapy. Spontaneous TLS is uncommon occurrence in multiple myeloma (MM). We define a case of a 70-year-old woman patient who was found to have MM with spontaneous TLS, following a comp...

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Spontaneous Tumor Lysis Syndrome

Tumor lysis syndrome (TLS) is a known complication of malignancy and its treatment. The incidence varies on malignancy type, but is most common with hematologic neoplasms during cytotoxic treatment. Spontaneous TLS is thought to be rare. This case study is of a 62-year-old female admitted with multisystem organ failure, with subsequent diagnosis of aggressive B cell lymphoma. On admission, labo...

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Tumour lysis syndrome: implications for cancer therapy.

The tumour lysis syndrome (TLS) is a group of metabolic abnormalities caused by rapid and unexpected release of cellular components into the circulation as a result of massive destruction of rapidly proliferating malignant cells. It usually develops in patients with hematologic malignancies like acute lymphoid leukemia, non-Hodgkin and Burkitt's lymphoma after initiation of chemotherapy or may,...

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Case report: acute tumour lysis syndrome.

INTRODUCTION Acute tumour lysis syndrome (ATLS) is a potentially lethal but preventable complication of oncological treatment. CLINICAL PICTURE We report a case of a patient with Burkitt's leukaemia who developed ATLS after treatment with chemotherapy. TREATMENT Standard preventive measures using aggressive hydration, urine alkalinisation and uricosuric agents were instituted before chemoth...

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Massive uric acid nephrolithiasis with progressive renal failure due to spontaneous tumour lysis syndrome

Tumour lysis syndrome (TLS) is a constellation of meta- bolic complications due to the rapid destruction of malignant cells, causing renal, cardiac or cerebral dysfunction. Electrolyte abnormalities include hyperuricaemia, hyperphosphataemia, hyperkalaemia and hypocalcaemia. TLS-induced renal failure is mainly caused by uric acid and calcium phosphate crystal deposition and usually develops fol...

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ژورنال

عنوان ژورنال: Canadian Medical Association Journal

سال: 2012

ISSN: 0820-3946,1488-2329

DOI: 10.1503/cmaj.111251